Ectopic Expression of Plasmodium vivax vir Genes in P. falciparum Affects Cytoadhesion via Increased Expression of Specific var Genes. Rehn T, Lubiana P, Nguyen THT, Pansegrau E, Schmitt M, Roth LK, Brehmer J, Roeder T, Cadar D, Metwally NG, Bruchhaus I. Microorganisms. 2022 Jun 9;10(6):1183.



Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Kouba T, Vogel D, Thorkelsson SR, Quemin ERJ, Williams HM, Milewski M, Busch C, Günther S, Grünewald K, Rosenthal M & Cusack S. 2021 Nat Commun 12, 7018.



Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1. Sellau J, Groneberg M, Fehling H, Thye T, Hoenow S, Marggraff C, Weskamm M, Hansen C, Stanelle-Bertram S, Kuehl S, Noll J, Wolf V, Metwally NG, Hagen SH, Dorn C, Wernecke J, Ittrich H, Tannich E, Jacobs T, Bruchhaus I, Altfeld M, Lotter H. Nat Commun. 2020 Jul 10;11(1):3459.

Enhanced tenacity of mycobacterial aerosols from necrotic neutrophils. Pfrommer E, Dreier C, Gabriel G, Dallenga T, Reimer R, Schepanski K, Scherließ R, Schaible UE, Gutsmann T (2020). Sci Rep. 2020 Jun 8;10(1):9159.

Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein. Vogel D, Thorkelsson SR, Quemin ERJ, Meier K, Kouba T, Gogrefe N, Busch C, Reindl S, Günther S, Cusack S, Grünewald K, Rosenthal M. Nucleic Acids Res. 2020 Jun 4;48(10):5749-5765.



Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation. Ring S, Eggers L, Behrends J, Wutkowski A, Schwudke D, Kröger A, Hierweger AM, Hölscher C, Gabriel G, Schneider BE. JCI Insight. 2019 Apr 18;5(10):e126533.

Comparative pathogenesis of Ebola virus and Reston virus infection in humanized mice. Escudero-Pérez B, Ruibal P, Rottstegge M, Lüdtke A, Port JR, Hartmann K, Gómez-Medina S, Müller-Guhl J, Nelson EV, Krasemann S, Rodríguez E, Muñoz-Fontela C. JCI Insight. 2019 Nov 1;4(21).

Sex differences in immunity. Lotter H, Altfeld M. 2019 Mar;41(2):133-135.

Synthesis and characterisation of alpha-carboxynitrobenzyl photocaged L-aspartates for applications in time-resolved structural biology. Zaitsev-Doyle JJ, Puchert A, Pfeifer Y, Yan H, Yorke BA, Müller-Werkmeister HM, Uetrecht C, Rehbein J, Huse N, Pearson AR, Sans M. RSC Adv. 2019 Mar 15;9:8695–8699.



Complex lipid metabolic remodeling is required for efficient hepatitis C virus replication. Hofmann S, Krajewski M, Scherer C, Scholz V, Mordhorst V, Truschow P, Schöbel A, Reimer R, Schwudke D, Herker E. Biochim Biophys Acta. 2018 Jun 6;1863(9):1041-1056.

Interleukin-9 promotes early mast cell-mediated expulsion of Strongyloides ratti but is dispensable for generation of protective memory. Reitz M, Hartmann W, Rüdiger N, Orinska Z, Brunn ML, Breloer M. Sci Rep. 2018 Jun 5;8(1):8636.



Characterisation of Plasmodium falciparum populations selected on the human endothelial receptors P-selectin, E-selectin, CD9 and CD151. Metwally NG, Tilly AK, Lubiana P, Roth LK, Dörpinghaus M, Lorenzen S, Schuldt K, Witt S, Bachmann A, Tidow H, Gutsmann T, Burmester T, Roeder T, Tannich E, Bruchhaus I. Sci Rep. 2017 Jun 22;7(1):4069.

Comprehensive Characterization of Cellular Immune Responses Following Ebola Virus Infection. Dahlke C, Lunemann S, Kasonta R, Kreuels B, Schmiedel S, Ly ML, Fehling SK, Strecker T, Becker S, Altfeld M, Sow A, Lohse AW, Muñoz-Fontela C, Addo MM. J Infect Dis. 2017 Jan 15;215(2):287-292.

Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections. Cimini E, Viola D, Cabeza-Cabrerizo M, Romanelli A, Tumino N, Sacchi A, Bordoni V, Casetti R, Turchi F, Martini F, Bore JA, Koundouno FR, Duraffour S, Michel J, Holm T, Zekeng EG, Cowley L, Garcia Dorival I, Doerrbecker J, Hetzelt N, Baum JHJ, Portmann J, Wölfel R, Gabriel M, Miranda O, Díaz G, Díaz JE, Fleites YA, Piñeiro CA, Castro CM, Koivogui L, Magassouba N, Diallo B, Ruibal P, Oestereich L, Wozniak DM, Lüdtke A, Becker-Ziaja B, Capobianchi MR, Ippolito G, Carroll MW, Günther S, Di Caro A, Muñoz-Fontela C, Agrati C. PLoS Negl Trop Dis. 2017 May 30;11(5):e0005645.

Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes. Lüdtke A, Ruibal P, Becker-Ziaja B, Rottstegge M, Wozniak DM, Cabeza-Cabrerizo M, Thorenz A, Weller R, Kerber R, Idoyaga J, Magassouba N, Gabriel M, Günther S, Oestereich L, Muñoz-Fontela C. J Infect Dis. 2016 Oct 15;214(suppl 3):S275-S280.

Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination. Lüdtke A, Ruibal P, Wozniak DM, Pallasch E, Wurr S, Bockholt S, Gómez-Medina S, Qiu X, Kobinger GP, Rodríguez E, Günther S, Krasemann S, Idoyaga J, Oestereich L, Muñoz-Fontela C. Sci Rep. 2017 Mar 3;7:43776.

Increased Proinflammatory Cytokine Levels in Prolonged Arthralgia in Ross River Virus Infection. Tappe D, Pérez-Girón JV, Gómez-Medina S, Günther S, Muñoz-Fontela C, Schmidt-Chanasit J. Emerg Infect Dis. 2017 Apr;23(4):702-704.

M. tuberculosis-Induced Necrosis of Infected Neutrophils Promotes Bacterial Growth Following Phagocytosis by Macrophages. Dallenga T, Repnik U, Corleis B, Eich J, Reimer R, Griffiths GW, Schaible UE. Cell Host Microbe. 2017 Oct 11;22(4):519-530.

Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study. Sissoko D, Duraffour S, Kerber R, Kolie JS, Beavogui AH, Camara AM, Colin G, Rieger T, Oestereich L, Pályi B, Wurr S, Guedj J, Nguyen THT, Eggo RM, Watson CH, Edmunds WJ, Bore JA, Koundouno FR, Cabeza-Cabrerizo M, Carter LL, Kafetzopoulou LE, Kuisma E, Michel J, Patrono LV, Rickett NY, Singethan K, Rudolf M, Lander A, Pallasch E, Bockholt S, Rodríguez E, Di Caro A, Wölfel R, Gabriel M, Gurry C, Formenty P, Keïta S, Malvy D, Carroll MW, Anglaret X, Günther S.Lancet Glob Health. 2017 Jan;5(1):e80-e88.

Sex differences in the C57BL/6 model of Mycobacterium tuberculosis infection. Dibbern J, Eggers L, Schneider BE. Sci Rep. 2017 Sep 8;7(1):10957. 

Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus. Liu X, Speranza E, Muñoz-Fontela C, Haldenby S, Rickett NY, Garcia-Dorival I, Fang Y, Hall Y, Zekeng EG, Lüdtke A, Xia D, Kerber R, Krumkamp R, Duraffour S, Sissoko D, Kenny J, Rockliffe N, Williamson ED, Laws TR, N'Faly M, Matthews DA, Günther S, Cossins AR, Sprecher A, Connor JH, Carroll MW, Hiscox JA. Genome Biol. 2017 Jan 19;18(1):4.



A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients. Hölscher C, Heitmann L, Owusu-Dabo E, Horstmann RD, Meyer CG, Ehlers S, Thye T. Mediators Inflamm. 2016;2016:4245028.

Association Between Malaria and Invasive Nontyphoidal Salmonella Infection in a Hospital Study: Accounting for Berkson's Bias. Krumkamp R, Kreuels B, Sarpong N, Boahen KG, Foli G, Hogan B, Jaeger A, Reigl L, Zeeb H, Marks F, Adu-Sarkodie Y, May J. Clin Infect Dis. 2016 Mar 15;62 Suppl 1:S83-9. 

Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase. Tappe D, Pérez-Girón JV, Zammarchi L, Rissland J, Ferreira DF, Jaenisch T, Gómez-Medina S, Günther S, Bartoloni A, Muñoz-Fontela C, Schmidt-Chanasit J. Med Microbiol Immunol. 2016 Jun;205(3):269-73.

Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever. Oestereich L, Lüdtke A, Ruibal P, Pallasch E, Kerber R, Rieger T, Wurr S, Bockholt S, Pérez-Girón JV, Krasemann S, Günther S, Muñoz-Fontela C. PLoS Pathog. 2016 May 18;12(5):e1005656.

Development of an antibody capture ELISA using inactivated Ebola Zaire Makona virus. Krähling V, Becker D, Rohde C, Eickmann M, Eroğlu Y, Herwig A, Kerber R, Kowalski K, Vergara-Alert J, Becker S; European Mobile Laboratory consortium. Med Microbiol Immunol. 2016 Apr;205(2):173-83.

Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever. Oestereich L, Rieger T, Lüdtke A, Ruibal P, Wurr S, Pallasch E, Bockholt S, Krasemann S, Muñoz-Fontela C, Günther S. J Infect Dis. 2016 Mar 15;213(6):934-8.

Epstein-Barr virus-induced gene 3 suppresses T helper type 1, type 17 and type 2 immune responses after Trypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation. Böhme J, Roßnagel C, Jacobs T, Behrends J, Hölscher C, Erdmann H. Immunology. 2016 Mar;147(3):338-48.

IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage. Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H. J Hepatol. 2016 May;64(5):1147-1157.

One Episode of Self-Resolving Plasmodium yoelii Infection Transiently Exacerbates Chronic Mycobacterium tuberculosis Infection. Blank J, Eggers L, Behrends J, Jacobs T, Schneider BE. Front Microbiol. 2016 Feb 15;7:152.

Sustained Elevated Cytokine Levels during Recovery Phase of Mayaro Virus Infection. Tappe D, Pérez-Girón JV, Just-Nübling G, Schuster G, Gómez-Medina S, Günther S, Muñoz-Fontela C, Schmidt-Chanasit J. Emerg Infect Dis. 2016 Apr;22(4):750-2.

TLR1 Variant H305L Associated with Protection from Pulmonary Tuberculosis. Meyer CG, Reiling N, Ehmen C, Ruge G, Owusu-Dabo E, Horstmann RD, Thye T. PLoS One. 2016 May 23;11(5):e0156046.

Unique human immune signature of Ebola virus disease in Guinea. Ruibal P, Oestereich L, Lüdtke A, Becker-Ziaja B, Wozniak DM, Kerber R, Korva M, Cabeza-Cabrerizo M, Bore JA, Koundouno FR, Duraffour S, Weller R, Thorenz A, Cimini E, Viola D, Agrati C, Repits J, Afrough B, Cowley LA, Ngabo D, Hinzmann J, Mertens M, Vitoriano I, Logue CH, Boettcher JP, Pallasch E, Sachse A, Bah A, Nitzsche K, Kuisma E, Michel J, Holm T, Zekeng EG, García-Dorival I, Wölfel R, Stoecker K, Fleischmann E, Strecker T, Di Caro A, Avšič-Županc T, Kurth A, Meschi S, Mély S, Newman E, Bocquin A, Kis Z, Kelterbaum A, Molkenthin P, Carletti F, Portmann J, Wolff S, Castilletti C, Schudt G, Fizet A, Ottowell LJ, Herker E, Jacobs T, Kretschmer B, Severi E, Ouedraogo N, Lago M, Negredo A, Franco L, Anda P, Schmiedel S, Kreuels B, Wichmann D, Addo MM, Lohse AW, De Clerck H, Nanclares C, Jonckheere S, Van Herp M, Sprecher A, Xiaojiang G, Carrington M, Miranda O, Castro CM, Gabriel M, Drury P, Formenty P, Diallo B, Koivogui L, Magassouba N, Carroll MW, Günther S, Muñoz-Fontela C. Nature. 2016 May 5;533(7601):100-4.



Ebola virus disease in mice with transplanted human hematopoietic stem cells. Lüdtke A, Oestereich L, Ruibal P, Wurr S, Pallasch E, Bockholt S, Ip WH, Rieger T, Gómez-Medina S, Stocking C, Rodríguez E, Günther S, Muñoz-Fontela C. J Virol. 2015 Apr;89(8):4700-4.

Human Invasive Muscular Sarcocystosis Induces Th2 Cytokine Polarization and Biphasic Cytokine Changes, Based on an Investigation among Travelers Returning from Tioman Island, Malaysia. Tappe D, Slesak G, Pérez-Girón JV, Schäfer J, Langeheinecke A, Just-Nübling G, Muñoz-Fontela C, Püllmann K. Clin Vaccine Immunol. 2015 Jun;22(6):674-7.

Mycobacterium tuberculosis Coinfection Has No Impact on Plasmodium berghei ANKA-Induced Experimental Cerebral Malaria in C57BL/6 Mice. Blank J, Behrends J, Jacobs T, Schneider BE. Infect Immun. 2015 Dec 7;84(2):502-10.

Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa. Carroll MW, Matthews DA, Hiscox JA, Elmore MJ, Pollakis G, Rambaut A, Hewson R, García-Dorival I, Bore JA, Koundouno R, Abdellati S, Afrough B, Aiyepada J, Akhilomen P, Asogun D, Atkinson B, Badusche M, Bah A, Bate S, Baumann J, Becker D, Becker-Ziaja B, Bocquin A, Borremans B, Bosworth A, Boettcher JP, Cannas A, Carletti F, Castilletti C, Clark S, Colavita F, Diederich S, Donatus A, Duraffour S, Ehichioya D, Ellerbrok H, Fernandez-Garcia MD, Fizet A, Fleischmann E, Gryseels S, Hermelink A, Hinzmann J, Hopf-Guevara U, Ighodalo Y, Jameson L, Kelterbaum A, Kis Z, Kloth S, Kohl C, Korva M, Kraus A, Kuisma E, Kurth A, Liedigk B, Logue CH, Lüdtke A, Maes P, McCowen J, Mély S, Mertens M, Meschi S, Meyer B, Michel J, Molkenthin P, Muñoz-Fontela C, Muth D, Newman EN, Ngabo D, Oestereich L, Okosun J, Olokor T, Omiunu R, Omomoh E, Pallasch E, Pályi B, Portmann J, Pottage T, Pratt C, Priesnitz S, Quartu S, Rappe J, Repits J, Richter M, Rudolf M, Sachse A, Schmidt KM, Schudt G, Strecker T, Thom R, Thomas S, Tobin E, Tolley H, Trautner J, Vermoesen T, Vitoriano I, Wagner M, Wolff S, Yue C, Capobianchi MR, Kretschmer B, Hall Y, Kenny JG, Rickett NY, Dudas G, Coltart CE, Kerber R, Steer D, Wright C, Senyah F, Keita S, Drury P, Diallo B, de Clerck H, Van Herp M, Sprecher A, Traore A, Diakite M, Konde MK, Koivogui L, Magassouba N, Avšič-Županc T, Nitsche A, Strasser M, Ippolito G, Becker S, Stoecker K, Gabriel M, Raoul H, Di Caro A, Wölfel R, Formenty P, Günther S. Nature. 2015 Aug 6;524(7563):97-101.

Type of in vitro cultivation influences cytoadhesion, knob structure, protein localization and transcriptome profile of Plasmodium falciparum. Tilly AK, Thiede J, Metwally N, Lubiana P, Bachmann A, Roeder T, Rockliffe N, Lorenzen S, Tannich E, Gutsmann T, Bruchhaus I. Sci Rep. 2015 Nov 16;5:16766.

Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications. Zammarchi L, Stella G, Mantella A, Bartolozzi D, Tappe D, Günther S, Oestereich L, Cadar D, Muñoz-Fontela C, Bartoloni A, Schmidt-Chanasit J. J Clin Virol. 2015 Feb;63:32-5.



A new class of synthetic anti-lipopolysaccharide peptides inhibits influenza A virus replication by blocking cellular attachment. Hoffmann J, Schneider C, Heinbockel L, Brandenburg K, Reimer R, Gabriel G. Antiviral Res. 2014 Apr;104:23-33.

WASH-driven actin polymerization is required for efficient mycobacterial phagosome maturation arrest. Kolonko M, Geffken AC, Blumer T, Hagens K, Schaible UE, Hagedorn M. Cell Microbiol. 2014 Feb;16(2):232-46.



IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment. Erdmann H, Roßnagel C, Böhme J, Iwakura Y, Jacobs T, Schaible UE, Hölscher C. Immunobiology. 2013 Jun;218(6):910-23.



A new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses. Krepstakies M, Lucifora J, Nagel CH, Zeisel MB, Holstermann B, Hohenberg H, Kowalski I, Gutsmann T, Baumert TF, Brandenburg K, Hauber J, Protzer U. J Infect Dis. 2012 Jun;205(11):1654-64.



MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection. Cramer JP, Lepenies B, Kamena F, Hölscher C, Freudenberg MA, Burchard GD, Wagner H, Kirschning CJ, Liu X, Seeberger PH, Jacobs T. Microbes Infect. 2008 Oct;10(12-13):1259-65.